Intelligence, Surveillance, Reconnaissance

  • Many NIH-funded research projects rely on vertebrate and invertebrate animals to study fundamentals of biology and physiology, to investigate pathological conditions, to build models of human diseases, and to design novel therapies and translational procedures. ORIP plays a vital role in the area of NIH-funded animal model research by supporting specialized animal research facilities and the...
  • Many NIH-funded research projects rely on vertebrate and invertebrate animals to study fundamentals of biology and physiology, to investigate pathological conditions, to build models of human diseases, and to design novel therapies and translational procedures. ORIP plays a vital role in the area of NIH-funded animal model research by supporting specialized animal research facilities and the...
  • Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by...
  • Overview   This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by...
  • View and Register for all TechRich Events on WBCNA's Website April 2015 1 – DCAA Seminar Series Session #1 8 – DCAA Seminar Series Session #2 15 – DCAA Seminar Series Session #3 22 – DCAA Seminar Series Session #4 22 – SBIR/STTR Class 29 – DCAA Seminar Series Session #5 May 2015 13 – Q3 Ideation Session 29 – Empowering Our Veterans June 2015 3 – Cyber Security Seminar 10 –...
  • Purpose The Small Business Innovation Research (SBIR) Program is an important National Institutes of Health (NIH) funding mechanism used to develop innovative solutions that address public health challenges. A major objective of the SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of biomedical technology...
  • Background The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is a Presidential project aimed at revolutionizing our understanding of the human brain.  By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and...
  • Background The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is a Presidential project aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and complex...
  • Background The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is a Presidential project aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and complex...
  • The zebrafish is used extensively by NIH funded investigators to examine many aspects of the basic biology of vertebrates and, in the past several years, has become an important model organism for a variety of human diseases. During fiscal year 2013, twenty of the NIH Institutes, Centers and Offices funded approximately 700 grants related to zebrafish research, with an investment totaling...
  • The zebrafish is used extensively by NIH funded investigators to examine many aspects of the basic biology of vertebrates and, in the past several years, has become an important model organism for a variety of human diseases. During fiscal year 2013, twenty of the NIH Institutes, Centers and Offices funded approximately 700 grants related to zebrafish research, with an investment totaling...
  • Despite advances in the treatment of chronic viral hepatitis B and C, the persistence of these and the emergence of other hepatitis viruses continue to remain a public health challenge in the United States. Currently, it is estimated that 3.5 to 5.3 million persons in the United States are afflicted by viral hepatitis. The consequences of acute and chronic viral hepatitis vary, but can be severe...
  • The NIH and other research sponsors provide significant funding to support the development of new technologies to support biomedical and behavioral research, through a variety of grant mechanisms, including NIH’s R01, R21, P01, P41, and P50 basic research grants. This investment has resulted in the development of innovative technologies, including hardware (e.g., instruments, devices, etc...
  • Despite advances in the treatment of chronic viral hepatitis B and C, the persistence of these and the emergence of other hepatitis viruses continue to remain a public health challenge in the United States. Currently, it is estimated that 3.5 to 5.3 million persons in the United States are afflicted by viral hepatitis. The consequences of acute and chronic viral hepatitis vary, but can be severe...
  • Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA.  The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by...
  • Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA.  The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by...
  • Background Twenty-five years after discovery of the gene that causes cystic fibrosis (CF), we now are witnessing the emergence of drug therapies that target the fundamental molecular dysfunctions associated with mutations in the CF transmembrane conductance regulator (CFTR) gene. While these novel therapies offer an exciting prospect for modifying disease outcomes in CF, they may complicate even...
  • A. Overview This FOA is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for neurological disorders and stroke (http://www.ninds.nih.gov/funding/areas/translational_research/index.htm) that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Devices (CREATE Devices, http...
  • Purpose The purpose of this initiative is to incentivize small businesses to generate new technologies and products for  delivering nucleic acids  into cells and tissues for the purpose of treatment or prevention of human disease.  Background There are thousands of rare diseases, and a substantial fraction of these are monogenic disorders, resulting from mutations in a single...
  • Purpose The purpose of this initiative is to incentivize small businesses to generate new technologies and products for  delivering nucleic acids  into cells and tissues for the purpose of treatment or prevention of human disease.  Background  There are thousands of rare diseases, and a substantial fraction of these are monogenic disorders, resulting from mutations in a...
  • A. Overview This FOA is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for neurological disorders and stroke (http://www.ninds.nih.gov/funding/areas/translational_research/index.htm) that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Devices (CREATE Devices, http...
  • A. Overview This FOA is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for neurological disorders and stroke (http://www.ninds.nih.gov/funding/areas/translational_research/index.htm) that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Devices (CREATE Devices, http...
  • Background Recent trends have created a large potential market for breakthrough medical solutions led by tissue engineered medical products.  For example, bioengineered trachea, vascular grafts, and other hollow-organ tissues have made entry into clinical studies, so sophisticated and more standardized bioreactors are critical for testing of complex, neo-organ technologies. ...
  • The SBIR/STTR Programs were recently reauthorized by the United States Congress with the SBIR/STTR Reauthorization Act of 2011(P.L. 112-81).  One change that was made to the SBIR program in this reauthorization was the authority for certain participating federal agencies to ‘issue a Phase II award to a small business concern that did not receive a Phase I award for that research/...
  • Background Recent trends have created a large potential market for breakthrough medical solutions led by tissue engineered medical products.  For example, bioengineered trachea, vascular grafts, and other hollow-organ tissues have made entry into clinical studies, so sophisticated and more standardized bioreactors are critical for testing of complex, neo-organ technologies. ...
  • A. Overview Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food...
  • A. Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biotechnology Products and Biologics (CREATE Bio) program is dedicated to biotechnology...
  • A. Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biotechnology Products and Biologics (CREATE Bio) program is dedicated to biotechnology...
  • The SBIR/STTR Programs were recently reauthorized by the United States Congress with the SBIR/STTR Reauthorization Act of 2011(P.L. 112-81).  One change that was made to the SBIR program in this reauthorization was the authority for certain participating federal agencies to ‘issue a Phase II award to a small business concern that did not receive a Phase I award for that research/...
  • The Women's Business Center of North Alabama (WBCNA) will now lead the TechRich project, a Small Business Administration (SBA) contract designed to capitalize on existing R...
  • Purpose To facilitate the cooperation and partnering of public and private funding organizations, universities, academic medical centers, research institutes, contract research organizations, biotechnology companies, and pharmaceutical companies in the advancement of interventions for stroke prevention, treatment, and rehabilitation, NINDS has formed the NIH Stroke Clinical Trials Research...
  • The NIH and other research sponsors invest a significant amount of funds in the development of new technologies to study the brain and behavior, from basic and clinical perspectives, through a variety of mechanisms, including, from NIH, the R01, R21, R33, P01, P41, and P50 grants. This investment has produced a large number of technologies that include hardware (e.g., instruments, devices, etc...
  • There are important technologies within the biomedical and biobehavioral space that do not require federal regulatory approvals as part of the technology development efforts, but that still require extraordinary time and effort to develop. The purpose of this FOA is to encourage applications for renewals of existing Phase II grants which are supporting research and development of such...
  •   Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the treatment...
  • Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the treatment of...
  • Glucagon, GLP-1 and GIP are related peptides that target G-protein coupled receptors with effects on glucose and lipid homeostasis.  Glucagon concentrations can be elevated in diabetes due to dysregulation of glucagon secretion, while the pancreatic beta-cell can be resistant to the insulinotropic effects of the incretins, both contributing to hyperglycemia.  GLP-1 mimetics are in...
  • Background The overarching goal of the STTR program at the National Institute of Mental Health (NIMH) is to support small businesses to develop technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment of mental disorders, and...
  • Background The overarching goal of the SBIR program at the National Institute of Mental Health (NIMH) is to support small businesses to develop technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment of mental disorders, and...
  • Background G-protein coupled receptor proteins (GPCRs) are membrane bound proteins that serve to modulate cellular activities. Many of the GPCRs have potential significance in healthy mental function and in mental disorders, including receptors for serotonin, glutamate, dopamine, opioids, GABA, orexins, somatostatin, muscarinic, cannabinoid, adrenergic, Neuropeptide Y, corticotropin releasing...
  • Background G-protein coupled receptor proteins (GPCRs) are membrane bound proteins that serve to modulate cellular activities. Many of the GPCRs have potential significance in healthy mental function and in mental disorders, including receptors for serotonin, glutamate, dopamine, opioids, GABA, orexins, somatostatin, muscarinic, cannabinoid, adrenergic, Neuropeptide Y, corticotropin releasing...
  • This Funding Opportunity Announcement (FOA) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that focus on development of technologies in biomedical computing, informatics, and Big Data science. This FOA is coordinated by the NIH Big Data Initiative (BD2K) and the Biomedical Information Science and Technology Initiative (BISTI) committees...
  • This Funding Opportunity Announcement (FOA) is encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that focus on development of technologies in biomedical computing, informatics, and Big Data science. This FOA is coordinated by the NIH Big Data Initiative (BD2K) and the Biomedical Information Science and Technology Initiative (BISTI)...
  • Awareness of the mechanisms of HIV persistence and latent reservoirs has greatly increased over the last decade.  The scientific community now agrees that the time has come to pursue research towards a cure for HIV.  In addition, eradication efforts are facilitated by the presence of a clear target, the integrated, latent HIV provirus in resting CD4+ T-cells. A few years ago, HIV cure...
  • Awareness of the mechanisms of HIV persistence and latent reservoirs has greatly increased over the last decade.  The scientific community now agrees that the time has come to pursue research towards a cure for HIV.  In addition, eradication efforts are facilitated by the presence of a clear target, the integrated, latent HIV provirus in resting CD4+ T cells.  A few years ago, HIV...
  • The SBIR/STTR Programs were recently reauthorized by the United States Congress with the SBIR/STTR Reauthorization Act of 2011 (P.L. 112-81).  One change that was made to the SBIR program in this reauthorization was the authority for certain participating federal agencies to ‘issue a Phase II award to a small business concern that did not receive a Phase I award for that research/...
  • Background Recent significant advances in genetics, the basic understanding of physiology, and the pathogenesis of disease coupled with technological advances in areas such as bioinformatics, chemical biology, synthetic chemistry, and protein engineering have provided a rich knowledge base and strong toolbox to identify and pursue new drug targets with the goal of generating new molecular...
  • Background Recent significant advances in genetics, the basic understanding of physiology, and the pathogenesis of disease coupled with technological advances in areas such as bioinformatics, chemical biology, synthetic chemistry, and protein engineering have provided a rich knowledge base and strong toolbox to identify and pursue new drug targets with the goal of generating new molecular...
  • Diabetes markedly impairs quality of life and shortens lifespan primarily through premature cardiovascular mortality, neuropathy, nephropathy, retinopathy and wound healing compromise. Those complications lead to coronary, cerebral and peripheral artery disease, blindness, renal failure, impaired cognitive function, painful nerve disorders, diabetic foot ulcers and amputation. In addition to its...
  • Diabetes markedly impairs quality of life and shortens lifespan primarily through premature cardiovascular mortality, neuropathy, nephropathy, retinopathy and wound healing compromise. Those complications lead to coronary, cerebral and peripheral artery disease, blindness, renal failure, impaired cognitive function, painful nerve disorders, diabetic foot ulcers and amputation. In addition to its...
  • By Terry Griffin, Project Manager Huntsville Advanced Defense Technology Cluster Information below describes how federal government agencies and departments have turned to cloud computing. As competition increases for contracts in an austere budget environment, it is essential for small businesses to understand the importance and application of cloud computing. “Cloud computing is...

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